The Development of Hypo-Immunogenic iPS Cells

“Hiding therapeutic cells (hypoimmunogenic or immune cloaked) from the immune system is intrinsically risky. Therefore, the development and use of these cells have to contain a system that replaces the missing tumour surveillance function.” (Dr. Andras Nagy)

On May 17th 2021, Dr. Andras Nagy was part of a panel at the International Society of Stem Cell Research (ISSCR).  The broader topic was the development of pluripotent-based cell therapies that can evade the host immune system as being key to “off the shelf” allogeneic approaches. The program highlighted several approaches in making and testing genetically-modified, hypo-immune cells and the regulatory considerations around their clinical/commercial use.

Click here to view the presentation on demand.

A copy of Dr. Nagy’s presentation on Making The Unsafe Safe is located here:

ISSCR_Nagy4

 

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