Recently published (27 May 2021) in Nature Communications, a highly respected peer-reviewed scientific journal:
Human stem cells harboring a suicide gene improve the safety and standardisation of neural transplants in Parkinsonian rats
…Here, we utilised a hPSC line carrying a FailSafeTM suicide gene (thymidine kinase linked to cyclinD1) to selectively ablate proliferative cells in order to improve safety and purity of neural transplantation in a Parkinsonian model. The engineered FailSafeTM hPSCs demonstrated robust ventral midbrain specification in vitro, capable of forming neural grafts upon transplantation. … These findings demonstrate the capacity of a suicide gene-based system to improve both the standardisation and safety of hPSC-derived grafts in a rat model of Parkinsonism.
The FailsafeTM suicide system significantly reduced numbers of neural and non-neural cells within VM progenitor grafts.
To read the full article:
de Luzy, I.R., Law, K.C.L., Moriarty, N. et al. Human stem cells harboring a suicide gene improve the safety and standardisation of neural transplants in Parkinsonian rats. Nat Commun 12, 3275 (2021). https://doi.org/10.1038/s41467-021-23125-9