Improving Safety and Purity of Neural Transplantation with FailSafe

Recently published (27 May 2021) in Nature Communications, a highly respected peer-reviewed scientific journal:

Human stem cells harboring a suicide gene improve the safety and standardisation of neural transplants in Parkinsonian rats

…Here, we utilised a hPSC line carrying a FailSafeTM suicide gene (thymidine kinase linked to cyclinD1) to selectively ablate proliferative cells in order to improve safety and purity of neural transplantation in a Parkinsonian model. The engineered FailSafeTM hPSCs demonstrated robust ventral midbrain specification in vitro, capable of forming neural grafts upon transplantation. … These findings demonstrate the capacity of a suicide gene-based system to improve both the standardisation and safety of hPSC-derived grafts in a rat model of Parkinsonism.

The FailsafeTM suicide system significantly reduced numbers of neural and non-neural cells within VM progenitor grafts.

To read the full article:

de Luzy, I.R., Law, K.C.L., Moriarty, N. et al. Human stem cells harboring a suicide gene improve the safety and standardisation of neural transplants in Parkinsonian rats. Nat Commun 12, 3275 (2021). https://doi.org/10.1038/s41467-021-23125-9

https://rdcu.be/cmaSD

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