FailSafe Cells

Islam R, Drecun S, Varga BV, Vonderwalde I, Siu R, Nagy A and Morshead CM (2021) Transplantation of Human Cortically-Specified Neuroepithelial Progenitor Cells Leads to Improved Functional Outcomes in a Mouse Model of Stroke. Front. Cell. Neurosci. 15:654290. doi: 10.3389/fncel.2021.654290

Ross PJ, Zhang WB, Mok RSF, Zaslavsky K, Deneault E, D’Abate L, Rodrigues DC, Yuen RKC, Faheem M, Mufteev M, Piekna A, Wei W, Pasceri P, Landa RJ, Nagy A, Varga B, Salter MW, Scherer SW, Ellis J.(2020) Synaptic Dysfunction in Human Neurons With Autism-Associated Deletions in PTCHD1-AS. Biol Psychiatry. 2020 Jan 15;87(2):139-149. doi: 10.1016/j.biopsych.2019.07.014. Epub 2019 Jul 29. PMID: 31540669 Free PMC article.

Payne SL, Tuladhar A, Obermeyer JM, Varga BV, Teal CJ, Morshead CM, Nagy A, Shoichet MS (2019). Initial cell maturity changes following transplantation in a hyaluronan-based hydrogel and impacts therapeutic success in the stroke-injured rodent brain. Biomaterials. 2019 Feb;192:309-322. doi: 10.1016/j.biomaterials.2018.11.020. Epub 2018 Nov 15. PMID: 30468998.

Liang Q, Monetti C, Shutova MV, Neely EJ, Hacibekiroglu S, Yang H, Kim C, Zhang P, Li C, Nagy K, Mileikovsky M, Gyongy I, Sung HK, Nagy A. (2018) Linking a cell-division gene and a suicide gene to define and improve cell therapy safety.
Nature. 2018.  Nov 21; 563(7733): 701-704 PMID: 30429614

Führmann T, Anandakumaran PN, Payne SL, Pakulska MM, Varga BV, Nagy A, Tator C, Shoichet MS.(2018) Combined delivery of chondroitinase ABC and human induced pluripotent stem cell-derived neuroepithelial cells promote tissue repair in an animal model of spinal cord injury. Biomed Mater. 2018 Feb 2;13(2):024103. doi: 10.1088/1748-605X/aa96dc. PMID: 29083317.

Payne SL, Anandakumaran PN, Varga BV, Morshead CM, Nagy A, Shoichet MS. (2018) In Vitro Maturation of Human iPSC-Derived Neuroepithelial Cells Influences Transplant Survival in the Stroke-Injured Rat Brain. Tissue Eng Part A. 2018 Feb;24(3-4):351-360. doi: 10.1089/ten.TEA.2016.0515. Epub 2017 Jul 11. PMID: 28594288.

iACT Stealth Cells

Harding, J., Vintersten-Nagy, K., Shutova, M., Yang, H., Tang, J., Massumi, M., Izadifar, M., Izadifar, Z., Zhang, P., Li, C., et al. and Nagy, A. (2019). Induction of long-term allogeneic cell acceptance and formation of immune privileged tissue in immunocompetent Hosts.
BioRxiv, 2019, doi:

Lanza R, Russell D, Nagy A.  (2019) Engineering universal cells that evade immune detection.
Nature Reviews | Immunology.  2019. Aug 15. doi: 10.1038/s41577-019-0200-1 [Epub head of print]. PMID: 31417198

Harding J, Vinterstein-Nagy K, Nagy A.  (2020) Universal Stem Cells: making the unsafe safe.
Cell Stem Cell.  2020. Aug 6, 27(2): 198-9. Letter re: Gonzalez BJ et al, (Cell Stem Cell 26:307-308, March 5, 2020).  PMID: 32763181


Further publications on FailSafe and iACT Stealth Cells may be found under Publications on the Nagy Lab

Publications from Dr. Armand Keating, co-founder of panCELLa, may be found under PubMed

The Universal Cell: Making the Unsafe Safe (Dr. Andras Nagy, November 10th, 2021)

A Failsafe suicide gene-based system to improve safety & standardisation of neural grafts (Clare Parish, November 10th 2021))