Fail Safe Cell Therapy


Reprogramming Mouse Fibroblasts with piggyBac Transposons

R Behringer, M Gertsenstein, KV Nagy, A Nagy
Cold Spring Harbor Protocols, 2017

Mouse embryonic fibroblasts can be reprogrammed to ES cell-like pluripotent stem cells by the forced
expression of four transcription factors—OCT4, SOX2, KLF4, and c-MYC. The piggyBac transposon system
has proven effective as a vehicle for the delivery of…


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