Failsafe - Pluristyx

FailSafe^®: Engineered safety for tomorrow’s cell therapies

Chimeric antigen receptor (CAR) T-cell therapies are a novel class of targeted and personalized immunotherapy which have shown remarkable success to date in treating certain hematological malignancies, including certain types of leukemia and lymphoma. There are currently six commercially available CAR T-Cell therapies: Abecma, Breyanzi, Kymriah, Tecartus, Yescarta, and Carvykti (Ghosh, 2023). There are a …

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In Vitro Maturation of Human iPSC-Derived Neuroepithelial Cells Influences Transplant Survival in the Stroke-Injured Rat Brain.

Publications / By Anaelle Do Rego

Payne SL, Anandakumaran PN, Varga BV, Morshead CM, Nagy A, Shoichet MS. (2018)  Tissue Eng Part A. 2018 Feb;24(3-4):351-360. doi: 10.1089/ten.TEA.2016.0515. Epub 2017 Jul 11. PMID: 28594288

Combined delivery of chondroitinase ABC and human induced pluripotent stem cell-derived neuroepithelial cells promote tissue repair in an animal model of spinal cord injury.

Publications / By Anaelle Do Rego

Führmann T, Anandakumaran PN, Payne SL, Pakulska MM, Varga BV, Nagy A, Tator C, Shoichet MS.(2018)  Biomed Mater. 2018 Feb 2;13(2):024103. doi: 10.1088/1748-605X/aa96dc. PMID: 29083317

Linking a cell-division gene and a suicide gene to define and improve cell therapy safety.

Publications / By Anaelle Do Rego

Liang Q, Monetti C, Shutova MV, Neely EJ, Hacibekiroglu S, Yang H, Kim C, Zhang P, Li C, Nagy K, Mileikovsky M, Gyongy I, Sung HK, Nagy A. (2018)  Nature. 2018.  Nov 21; 563(7733): 701-704 PMID: 30429614

Initial cell maturity changes following transplantation in a hyaluronan-based hydrogel and impacts therapeutic success in the stroke-injured rodent brain.

Publications / By Anaelle Do Rego

Payne SL, Tuladhar A, Obermeyer JM, Varga BV, Teal CJ, Morshead CM, Nagy A, Shoichet MS (2019). Biomaterials. 2019 Feb;192:309-322. doi:10.1016/j.biomaterials.2018.11.020. Epub 2018 Nov 15. PMID: 30468998

Synaptic Dysfunction in Human Neurons With Autism-Associated Deletions in PTCHD1-AS

Publications / By Anaelle Do Rego

Ross PJ, Zhang WB, Mok RSF, Zaslavsky K, Deneault E, D’Abate L, Rodrigues DC, Yuen RKC, Faheem M, Mufteev M, Piekna A, Wei W, Pasceri P, Landa RJ, Nagy A, Varga B, Salter MW, Scherer SW, Ellis J.(2020)  Biol Psychiatry. 2020 Jan 15;87(2):139-149. doi: 10.1016/j.biopsych.2019.07.014. Epub 2019 Jul 29. PMID: 31540669 Free PMC article.

Transplantation of Human Cortically-Specified Neuroepithelial Progenitor Cells Leads to Improved Functional Outcomes in a Mouse Model of Stroke. 

Publications / By Anaelle Do Rego

Islam R, Drecun S, Varga BV, Vonderwalde I, Siu R, Nagy A and Morshead CM (2021) Front. Cell. Neurosci. 15:654290. doi:10.3389/fncel.2021.654290