Fail Safe Cell Therapy


Uterine-Derived Stem Cells Reconstitute the Bone Marrow of Irradiated Mice

Zhuo Sun, Jun Wu, Shu-Hong Li, Yuemei Zhang, Munira Xaymardan, Xiao-Yan Wen, Richard D Weisel, Armand Keating, Ren-Ke Li
Stem Cells Dev 2015 Apr 7;24(8):938-47. Epub 2015 Jan 7.

Hematopoietic stem cells (HSCs) can be found in several tissues of mesodermal origin. Uterine tissue contains stem cells and can regenerate during each menstrual cycle with robust new tissue formation. Stem cells may play a role in this regenerative potential. Here, we report that transplantation of cells isolated from murine uterine tissue can rescue lethally irradiated mice and reconstitute the major hematopoietic lineages….


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